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Year Number of Results
1979 1
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1993 5
1994 11
1995 7
1996 4
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1998 8
1999 3
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2002 8
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2006 22
2007 19
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2009 26
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2024 20

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863 results

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Page 1
Did you mean bile and liver (73,775 results)?
Empagliflozin Attenuates Non-Alcoholic Fatty Liver Disease (NAFLD) in High Fat Diet Fed ApoE((-/-)) Mice by Activating Autophagy and Reducing ER Stress and Apoptosis.
Nasiri-Ansari N, Nikolopoulou C, Papoutsi K, Kyrou I, Mantzoros CS, Kyriakopoulos G, Chatzigeorgiou A, Kalotychou V, Randeva MS, Chatha K, Kontzoglou K, Kaltsas G, Papavassiliou AG, Randeva HS, Kassi E. Nasiri-Ansari N, et al. Int J Mol Sci. 2021 Jan 15;22(2):818. doi: 10.3390/ijms22020818. Int J Mol Sci. 2021. PMID: 33467546 Free PMC article.
At the end of treatment, histomorphometric analysis was performed in liver, mRNA levels of Fasn, Screbp-1, Scd-1, Ppar-gamma, Pck-1, Mcp-1, Tnf-alpha, Il-6, F4/80, Atf4, Elf2alpha, Chop, Grp78, Grp94, chibp1, Ire1alpha, Atf6, mTor, Lc3b, Beclin-1, P62, Bcl-2 and Bax were m …
At the end of treatment, histomorphometric analysis was performed in liver, mRNA levels of Fasn, Screbp-1, Scd-1, Ppar-gamma, Pck-1, …
Decoding cell death signals in liver inflammation.
Brenner C, Galluzzi L, Kepp O, Kroemer G. Brenner C, et al. J Hepatol. 2013 Sep;59(3):583-94. doi: 10.1016/j.jhep.2013.03.033. Epub 2013 Apr 6. J Hepatol. 2013. PMID: 23567086 Free article. Review.
Inflammation can be either beneficial or detrimental to the liver, depending on multiple factors. Mild (i.e., limited in intensity and destined to resolve) inflammatory responses have indeed been shown to exert consistent hepatoprotective effects, contributing to tissue re …
Inflammation can be either beneficial or detrimental to the liver, depending on multiple factors. Mild (i.e., limited in intensity an …
Experimental Nonalcoholic Steatohepatitis and Liver Fibrosis Are Ameliorated by Pharmacologic Activation of Nrf2 (NF-E2 p45-Related Factor 2).
Sharma RS, Harrison DJ, Kisielewski D, Cassidy DM, McNeilly AD, Gallagher JR, Walsh SV, Honda T, McCrimmon RJ, Dinkova-Kostova AT, Ashford MLJ, Dillon JF, Hayes JD. Sharma RS, et al. Cell Mol Gastroenterol Hepatol. 2017 Dec 13;5(3):367-398. doi: 10.1016/j.jcmgh.2017.11.016. eCollection 2018 Mar. Cell Mol Gastroenterol Hepatol. 2017. PMID: 29552625 Free PMC article.
Measures of whole-body glucose homeostasis, histologic assessment of liver, and biochemical and molecular measurements of steatosis, endoplasmic reticulum (ER) stress, inflammation, apoptosis, fibrosis, and oxidative stress were performed in livers from these animal …
Measures of whole-body glucose homeostasis, histologic assessment of liver, and biochemical and molecular measurements of steatosis, …
Silica nanoparticles aggravated the metabolic associated fatty liver disease through disturbed amino acid and lipid metabolisms-mediated oxidative stress.
Abulikemu A, Zhao X, Xu H, Li Y, Ma R, Yao Q, Wang J, Sun Z, Li Y, Guo C. Abulikemu A, et al. Redox Biol. 2023 Feb;59:102569. doi: 10.1016/j.redox.2022.102569. Epub 2022 Dec 5. Redox Biol. 2023. PMID: 36512914 Free PMC article.
The metabolic associated fatty liver disease (MAFLD) is a public health challenge, leading to a global increase in chronic liver disease. ...In particular, the identified differential metabolites were strongly correlated to the activation of oxidative stress and ens …
The metabolic associated fatty liver disease (MAFLD) is a public health challenge, leading to a global increase in chronic liver …
Endoplasmic reticulum stress in liver disease.
Malhi H, Kaufman RJ. Malhi H, et al. J Hepatol. 2011 Apr;54(4):795-809. doi: 10.1016/j.jhep.2010.11.005. Epub 2010 Nov 13. J Hepatol. 2011. PMID: 21145844 Free PMC article. Review.
The unfolded protein response (UPR) is activated upon the accumulation of misfolded proteins in the endoplasmic reticulum (ER) that are sensed by the binding immunoglobulin protein (BiP)/glucose-regulated protein 78 (GRP78). The accumulation of unfolded proteins sequesters …
The unfolded protein response (UPR) is activated upon the accumulation of misfolded proteins in the endoplasmic reticulum (ER) that are sens …
Isovitexin protects against acute liver injury by targeting PTEN, PI3K and BiP via modification of m6A.
Huang Y, Chen S, Pang L, Feng Z, Su H, Zhu W, Wei J. Huang Y, et al. Eur J Pharmacol. 2022 Feb 15;917:174749. doi: 10.1016/j.ejphar.2022.174749. Epub 2022 Jan 7. Eur J Pharmacol. 2022. PMID: 35007522
Isovitexin (IVT) has been shown to have a potential therapeutic effect on acute liver injury (ALI), but its underlying mechanisms especially the targets remain unclear, which was investigated in the present study. ...Notably, IVT significantly decreased total hepatic m6A l …
Isovitexin (IVT) has been shown to have a potential therapeutic effect on acute liver injury (ALI), but its underlying mechanisms esp …
Functions and pathologies of BiP and its interaction partners.
Dudek J, Benedix J, Cappel S, Greiner M, Jalal C, Müller L, Zimmermann R. Dudek J, et al. Cell Mol Life Sci. 2009 May;66(9):1556-69. doi: 10.1007/s00018-009-8745-y. Cell Mol Life Sci. 2009. PMID: 19151922 Review.
Furthermore, the inherited diseases Marinesco-Sjogren syndrome, autosomal dominant polycystic liver disease, Wolcott-Rallison syndrome, and several cancer types can be considered BiP-related diseases. This review summarizes the physiological and pathophysiological c …
Furthermore, the inherited diseases Marinesco-Sjogren syndrome, autosomal dominant polycystic liver disease, Wolcott-Rallison syndrom …
(+)-Lipoic acid reduces mitochondrial unfolded protein response and attenuates oxidative stress and aging in an in vitro model of non-alcoholic fatty liver disease.
Longhitano L, Distefano A, Musso N, Bonacci P, Orlando L, Giallongo S, Tibullo D, Denaro S, Lazzarino G, Ferrigno J, Nicolosi A, Alanazi AM, Salomone F, Tropea E, Barbagallo IA, Bramanti V, Li Volti G, Lazzarino G, Torella D, Amorini AM. Longhitano L, et al. J Transl Med. 2024 Jan 20;22(1):82. doi: 10.1186/s12967-024-04880-x. J Transl Med. 2024. PMID: 38245790 Free PMC article.
BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is a liver disorder characterized by the ac-cumulation of fat in hepatocytes without alcohol consumption. ...PA:OA (palmitic acid:oleic acid)-induced ER stress markers IRE1alpha (Inositol requiring enzyme-1), CHO …
BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is a liver disorder characterized by the ac-cumulation of fat in hepatoc …
Nebivolol protects the liver against lipopolysaccharide-induced oxidative stress, inflammation, and endoplasmic reticulum-related apoptosis through Chop and Bip/GRP78 signaling.
Unal O, Erzurumlu Y, Asci H, Gunduru Acar B, Bedir M, Ozmen O. Unal O, et al. Naunyn Schmiedebergs Arch Pharmacol. 2024 Feb 14. doi: 10.1007/s00210-024-02990-3. Online ahead of print. Naunyn Schmiedebergs Arch Pharmacol. 2024. PMID: 38353687
This study aimed to examine the protective role of nebivolol (NEB) on liver tissue against the lipopolysaccharide (LPS)-induced sepsis model in rats by targeting endoplasmic reticulum (ER) stress-related binding immunoglobulin protein (Bip), CCAAT-enhancer-binding p …
This study aimed to examine the protective role of nebivolol (NEB) on liver tissue against the lipopolysaccharide (LPS)-induced sepsi …
The N-degron pathway mediates lipophagy: The chemical modulation of lipophagy in obesity and NAFLD.
Jung EJ, Sung KW, Bae TH, Kim HY, Choi HR, Kim SH, Jung CH, Mun SR, Son YS, Kim S, Suh YH, Kashina A, Park JW, Kwon YT. Jung EJ, et al. Metabolism. 2023 Sep;146:155644. doi: 10.1016/j.metabol.2023.155644. Epub 2023 Jun 28. Metabolism. 2023. PMID: 37385404
BACKGROUND AND AIMS: Central to the pathogenesis of nonalcoholic fatty liver disease (NAFLD) is the accumulation of lipids in the liver and various fat tissues. ...This autophagic degradation initiates when the molecular chaperones including BiP/GRP78, retro- …
BACKGROUND AND AIMS: Central to the pathogenesis of nonalcoholic fatty liver disease (NAFLD) is the accumulation of lipids in the …
863 results